This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM).
The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed.
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